利伐沙班在心力衰竭窦性心律和冠状动脉疾

Thrombinn.凝血酶

Rivaroxabann.利伐沙班

Heartfailureisassociatedwithactivationofthrombin-relatedpathways,whichpredictsapoorprognosis.IntheCOMMANDERHFTrial,patientswhohadchronicheartfailure,aleftventricularejectionfractionof40%orless,coronaryarterydisease,andelevatedplasmaconcentrationsofnatriureticpeptidesandwhodidnothaveatrialfibrillationwererandomlyassignedtoreceiverivaroxabanatadoseof2.5mgtwicedailyorplaceboinadditiontostandardcareaftertreatmentforanepisodeofworseningheartfailure.Overamedianfollow-upperiodof21.1months,theprimaryendpointofdeathfromanycause,myocardialinfarction,orstrokeoccurredin25.0%patientsofrivaroxabanand26.2%patientsofplacebo.Nosignificantdifferenceinall-causemortalitywasnotedbetweentherivaroxabangroupandtheplacebogroup(21.8%and22.1%,respectively).Theprincipalsafetyout







































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