实验为了探讨不同冠脉病变程度冠心病患者氧化低密度脂蛋白(ox-LDL)、肿瘤坏死因子-α(TNF-α)水平变化及其相关性。
Toexplorechangesofoxidizedlowdensitylipoprotein(ox-LDL)andtumornecrosisfactor(TNF)-αcontentinpatientswithdifferentdegreescoronaryheartdisease(CHD)andtheircorrelation.
选择例冠脉造影确诊为冠心病的患者(冠心病组),分为:稳定型心绞痛(SAP)组(23例)、不稳定型心绞痛(UAP)组(48例)、急性心肌梗死(AMI)组(29例);单支组(31例)、双支组(33例)、多支病变组(36例);轻度狭窄组(27例)、中度狭窄组(31例)、重度狭窄组(42例)。选择同期体检无冠心病及严重器质性病变的中老年人30例为健康对照组。测定各组TC、TG、HDL-C、LDL-C、ox-LDL及TNF-α水平。
AtotalofCHDpatientsdiagnosedbycoronaryangiography(CAG)wereselectedanddividedintostableanginapectoris(SAP)group(n=23),unstableanginapectoris(UAP)group(n=48)andacutemyocardialinfarction(AMI)group(n=29);singlevesselgroup(n=31),doublevesselgroup(n=33)andmulti-vesseldiseasegroup(n=36);mildstenosisgroup(n=27),moderatestenosisgroup(n=31)andseverestenosisgroup(n=42).Atotalof30middle-agedandagedpeoplewithoutCHDandsevereorganicdiseases,wereenrolledashealthycontrolgroup.Contentoftotalcholesterol(TC),triglyceride(TG),highdensitylipoproteincholesterol(HDL-C),lowdensitylipoproteincholesterol(LDL-C),ox-LDLandTNF-αweremeasuredamongabovegroups.
结果发现冠心病组患者血脂(除HDL-C)和TNF-α水平均显著高于健康对照组(P0.05或0.01),HDL-C显著低于健康对照组(P0.05);UAP组、AMI组ox-LDL、TNF-α水平显著高于SAP组、UAP组(P均0.05);双支、多支病变组ox-LDL[(.47±84.21)μg/L、(.31±88.49)μg/L比(.19±80.75)μg/L]、TNF-α[(10.06±2.78)ng/L、(11.14±2.74)ng/L比(9.01±2.75)ng/L]水平显著高于单支病变组(P0.05),多支病变组高于双支病变组(P0.05);中度、重度狭窄组ox-LDL[(.33±68.12)μg/L、(.62±93.43)μg/L比(.43±53.36)μg/L]、TNF-α[(9.94±2.87)ng/L、(11.12±3.21)ng/L比(8.98±2.66)ng/L]水平显著高于轻度狭窄组(P0.05),重度狭窄组显著高于中度狭窄组(P0.05);Spearman相关分析显示,ox-LDL与TNF-α水平呈正相关(r=0.83,P0.01)。
Comparedwithhealthycontrolgroup,thereweresignificantincreaseinbloodlipidlevels(exceptHDL-C),TNF-αlevel,andsignificantdecreaseinHDL-ClevelinCHDgroup,P0.05all;
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