FreeThiolβ2-GPI(β-2-Glycoprotein-I)ProvidesaLinkBetweenInflammationandOxidativeStressinAtheroscleroticCoronaryArteryDiseaseATVBresearch-articleEarlyRecent,Sept17,./ATVBAHA..本文由“天纳”临床学术信息人工智能系统自动翻译点击文末“阅读原文”下载本文PDFObjective:Atheroscleroticcoronaryarterydiseaseiswellrecognisedasaninflammatorydisorderthatisalsoinfluencedbyoxidativestress.β2-GPI(β-2-glycoprotein-I)isacirculatingplasmaproteinthatundergoespost-translationalmodificationandexistsinfreethiolaswellasoxidizedforms.Theaimofthisstudywastoassesstheassociationbetweenthese2post-translationalredoxformsofβ2-GPIandatheroscleroticcoronaryarterydisease.动脉粥样硬化性冠状动脉疾病是公认的炎症性疾病，也受到氧化应激的影响。β2-GPI（β2-glycoprotein-I）是一种经过翻译后修饰的循环血浆蛋白，以游离巯基和氧化态形式存在。本研究的目的是评估这两种β2-GPI翻译后氧化还原形式与动脉粥样硬化性冠状动脉疾病之间的关系。ApproachandResults:StablepatientspresentingforelectivecoronaryangiographyorCTcoronaryangiographywereprospectivelyrecruited.AseparategroupofpatientsafterreperfusedST-segment–elevationmyocardialinfarctionformedanacutecoronarysyndromesubgroup.Allpatientshadcollectionoffastingserumandplasmaforquantificationoftotalandfreethiolβ2-GPI.CoronaryarterydiseaseextentwasquantifiedbytheSyntaxandGensiniscores.Atotalofpatientswithstablediseaseand44withacutecoronarysyndromewererecruited.Whiletotalβ2-GPIwasnotassociatedwithstablecoronaryarterydisease,ahigherfreethiolβ2-GPIwasassociatedwithitspresenceandextent.Thisfindingremainedsignificantaftercorrectingforconfoundingvariables,andfreethiolβ2-GPIwasabetterpredictorofstablecoronaryarterydiseasethanhigh-sensitivityC-reactiveprotein.Paradoxically,therewerelowerlevelsoffreethiolβ2-GPIafterST-segment–elevationmyocardialinfarction.前瞻性招募有选择性冠状动脉造影或CT冠状动脉造影表现的稳定患者。再灌注ST段抬高心肌梗死后的一组患者形成了急性冠脉综合征亚组。所有患者均采集空腹血清和血浆，测定总巯基β2-GPI和游离巯基β2-GPI。以Syntax评分和Gensini评分量化冠状动脉病变程度。共招募了名病情稳定的患者和44名急性冠脉综合征患者。总β2-GPI与稳定型冠心病无关，但较高的游离巯基β2-GPI与稳定型冠心病的存在和程度有关。这一发现在校正混杂变量后仍然显著，游离巯基β2-GPI比高敏C-反应蛋白更能预测稳定的冠状动脉疾病。矛盾的是，ST段抬高心肌梗死后游离巯基β2-GPI水平较低。Conclusions:Freethiolβ2-GPIisapredictorofcoronaryarterydiseasepresenceandextentinstablepatients.Freethiolβ2-GPIwasabetterpredictorthanhigh-sensitivityC-reactiveprotein.在稳定期患者中，游离巯基β2-GPI可预测冠心病的存在和程度。游离巯基β2-GPI比高敏C-反应蛋白更能预测细胞凋亡。Footnotes*Theseauthorscontributedequallytothisarticle.TheDataSupplementisavailablewiththisarticleat
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