BACKGROUND
TheFractionalFlowReserveversusAngiographyforMultivesselEvaluation(FAME)2trialwasdesignedtotargetstenosescapableofinducingischemia(FFR,≤0.80)inalargemyocardialterritoryandtorefrainfromPCIinpatientswithhemodynamicallynonsignificantstenoses(FFR,0.80).
Wehypothesizedthatfractionalflowreserve(FFR)–guidedpercutaneouscoronaryintervention(PCI)wouldbesuperiortomedicaltherapyasinitialtreatmentinpatientswithstablecoronaryarterydisease.
背景
血流储备分数和血管造影用于多血管评估的比较（FractionalFlowReserveversusAngiographyforMultivesselEvaluation，FAME）2试验旨在靶向可诱导大面积心肌缺血（FFR≤0.80）的狭窄，并避免对血流动力学不显著（FFR＞0.80）的狭窄患者进行PCI治疗。
我们假设，在稳定型冠心病患者中，作为初始治疗，血流储备分数（FFR）指导下的经皮冠状动脉介入治疗（PCI）优于药物治疗。
METHODS
Amongpatientswithangiographicallysignificantstenoses,thoseinwhomatleastonestenosiswashemodynamicallysignificant(FFR,≤0.80)wererandomlyassignedtoFFR-guidedPCIplusmedicaltherapyortomedicaltherapyalone.
PatientsinwhomallstenoseshadanFFRofmorethan0.80receivedmedicaltherapyandwereenteredintoaregistry.Theprimaryendpointwasa
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