TODAY今日发布JCardiovascMagnResonDec01,:21(1)今日发布01篇(共计66篇)BMC?CardiovascDisordDec01,:19(1)今日发布01篇(共计篇)CardiovascUltrasoundDec01,:17(1)今日发布01篇(共计21篇)EuropeanHeartJournal-CardiovascularImagingNov01,:20(11)今日发布08篇(共计25篇)CirculationResearchEarlyRecent,Oct28,今日发布01篇EurHeartJAcuteCardiovascCareEarlyRecent,Oct28,今日发布01篇JAMAINTERNMEDEarlyRecent,Oct28,今日发布10篇JAMAEarlyRecent,Oct28,今日发布01篇CirculationOct29,:(18)今日发布15篇StrokeNov01,:50(11)今日发布78篇JACCNov05,:74(18),-今日发布22篇JACC:HeartFailureNov01,:7(11),-今日发布17篇EurJPrevCardiolEarlyRecent,Oct29,今日发布01篇CircHeartFailNov01,:12(11)今日发布02篇StrokeEarlyRecent,Oct29,今日发布03篇EuropeanStrokeJournalEarlyRecent,Oct29,今日发布01篇RECOMMEND推荐阅读01血脂与缺血性和出血性卒中的关系Strokeresearch-articleXiaoyingGu,YunzhiLi,etc.2小时前等20用户推荐阅读本文BackgroundandPurposePreviousresultsontheassociationbetweenlipidsandstrokewerecontroversial.Weinvestigatedtheassociationoftotalcholesterol(TC),low-densitylipoproteincholesterol(LDL-C),high-densitylipoproteincholesterol(HDL-C),andtriglyceridewithstroke.先前关于血脂与中风之间关系的研究结果存在争议。我们研究了总胆固醇(tc)、低密度脂蛋白胆固醇(ldl-c)、高密度脂蛋白胆固醇(hdl-c)和甘油三酯与中风的关系。MethodsSixcohortstudiesinChinawithparticipantswereincluded.Coxproportionalhazardsregressionmodelsandrestrictedcubicsplineanalyseswereusedtoestimatehazardratiosand95%CIsandexplorelinearandnonlinearrelationshipsoflipidsandstroke,respectively.在中国进行了6项队列研究,共有名参与者。采用cox比例风险回归模型和限制性三次样条分析方法,分别估计危险比和95%cis,探讨血脂与脑卒中的线性和非线性关系。ResultsThemedianfollow-updurationrangedfrom6to19years.Duringperson-years,peopledevelopedstroke.Multivariableadjustedhazardratios(95%CIs)per1mmol/LincreaseinTC,LDL-C,triglyceridewere1.08(1.05–1.11),1.08(1.04–1.11),1.07(1.05-1.09)forischemicstroke,respectively.ComparedwithparticipantswithTC-.9mg/dL,hazardratios(95%CIs)were1.43(1.11–1.85)forhemorrhagicstrokeinthosewithTCmg/dL.ComparedwithparticipantswithHDL-C50to59.9mg/dL,hazardratios(95%CIs)were1.23(1.12–1.35),1.13(1.04–1.22)forischemicstroke,and1.28(1.10–1.49),1.17(1.03–1.33)forhemorrhagicstrokeinthosewithHDL-C40and40to49.9mg/dL,respectively.RestrictedcubicsplineanalysesshowedlinearrelationshipsofTCandLDL-C,andnonlinearrelationshipsofHDL-Candtriglyceridewithischemicstroke(allP0.).HemorrhagicstrokeshowedlinearrelationshipswithTCandHDL-C(P=0.and0.respectively),butnorelationshipwithLDL-Candtriglyceride(allP0.05).中位随访时间为6-19年。人年中,人患中风。对于缺血性卒中,tc、ldl-c、甘油三酯每增加1mmol/l,多变量校正危险比(95%cis)分别为1.08(1.05-1.11)、1.08(1.04-1.11)、1.07(1.05-1.09)。与tc-.9mg/dl组相比,tcmg/dl组出血性卒中的危险比(95%cis)为1.43(1.11-1.85)。与hdl-c50-59.9mg/dl的受试者相比,hdl-c40和40-49.9mg/dl的受试者缺血性卒中的危险比(95%cis)分别为1.23(1.12-1.35)、1.13(1.04-1.22)和1.28(1.10-1.49)、1.17(1.03-1.33)。限制三次样条分析显示tc和ldl-c呈线性关系,hdl-c和甘油三酯与缺血性卒中呈非线性关系(均p0.)。出血性卒中与tc、hdl-c呈线性关系(p分别为0.和0.),与ldl-c、甘油三酯无相关性(p均0.05)。ConclusionsTC,LDL-C,andtriglycerideshowedpositiveassociationswithischemicstroke.TheriskofhemorrhagicstrokewashigherwhenTCwaslowerthanmg/dL.LDL-Candtriglycerideshowednoassociationwithhemorrhagicstroke.TherisksofischemicandhemorrhagicstrokemightbehigherwhenHDL-Cwaslowerthan50mg/dL.tc、ldl-c和甘油三酯与缺血性卒中呈正相关。tc低于mg/dl时,出血性卒中的危险性较高。ldl-c和甘油三酯与出血性卒中无相关性。当hdl-c低于50mg/dl时,缺血性和出血性卒中的风险可能更高。扫描
北京中科白癜风医院公益抗白北京中科白癜风医院公益中国
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